Drug information provided by: IBM Micromedex. When is the best time of day to take letrozole? If possible, give them the name of the drug, your oncologist, and cancer center where you receive immunotherapy. Merely 12 cases of cutaneous adverse reactions induced by aromatase inhibitors, namely erythema nodosum (6), subacute cutaneous lupus erythematosus (1), cutaneous rashes (2), vasculitis (3, including the one described in this study), are reported in the literature. Advertising revenue supports our not-for-profit mission. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you have ringworm, it usually appears as a circular, patchy rash thats itchy. The phase IV clinical study analyzes which people take Anastrozole and have Rashes. The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. Theyre usually purple, red, or brown in color and are about the size of a pinpoint. Indications and dose For letrozole First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer, Adjuvant treatment of oestrogen-receptor-positive invasive early breast cancer in postmenopausal women, Advanced breast cancer in postmenopausal women (naturally or artificially induced menopause) in whom other anti-oestrogen therapy has failed, Extended adjuvant . Hello all and blessings. Hi Alicia, I have had Hidradenitis (HS) for about 20 yrs, in my groin and armpits. Depending on the severity of the side effect, your doctor may pause or permanently stop treatment with the immune checkpoint inhibitor. Call your doctor for medical advice about side effects. Aromasin (exemestane) is a prescription drug that's used to treat certain types of breast cancer. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Sorafenib (Nexavar) and sunitinib (Sutent). a buildup of the drug that causes toxicity to the skin. Do not drive or operate machinery until you know how the medication affects you. Apply more than half a teaspoon of sunscreen to each arm, your face, and your neck. He's also prescribed antihistamine tablets. exemestane) are increasingly incorporated into the treatment strategy of breast cancer patients, it is important to recognize possible cutaneous adverse effects. Avoid soaps with strong scents. Do not keep outdated medicine or medicine no longer needed. Femara is used to treat breast cancer in women who are post-menopausal - that is, women who no longer have periods, either naturally due to their age or after surgery or chemotherapy. For hand/foot skin reactions to the targeted therapies sorafenib and sunitinib: Use creams containing urea called carmol 20 or carmol 40, or salicylic acid (multiple brand names). a drug makes the skin more sensitive to sunlight . Its been a struggle but I managed fine. drug-induced hot flashes. "It doesn't have to be this painful p. top of page. There are some similarities and differences in side effects between these types of cancer medications compared to chemotherapy drugs. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. These side effects may go away during treatment as your body adjusts to the medicine. There is a problem with
Centers for Disease Control and Prevention. Joint or mu Information for Patients and Families. 39,784 people reported to have side effects when taking Letrozole. Whats Causing My Rash and Swollen Lymph Nodes? Your personal risk for developing a drug rash may be higher if you have certain risk factors, such as being older and being female. information is beneficial, we may combine your email and website usage information with
This site needs JavaScript to work properly. Clinical particulars. Letrozole (Femara ) is an oral medication that your doctor has prescribed for the treatment of your hormone-receptor-positive breast cancer. It's unlikely that your skin rash is related to leukemia, but in rare cases, it can be a sign. Thanks Carolyn. You can use the study as a second opinion to make health care decisions. Use a sunscreen with a sun protection factor (SPF) of at least 15. Letrozole and allergy rash. Cerner Multum, Inc. "UK Summary of Product Characteristics." Like other cancer treatments, they often cause side effects. If you ever need to talk about your HS, feel free to ask. Itching is common in many drug rashes. 1. The next day I was concerned because my face was swelling. Physical, Emotional, and Social Effects of Cancer, Skin Reactions to Targeted Therapy and Immunotherapy. However, only since my mastectomy and taking Letrozole I started to develop a skin condition which my dermatologist said was called Hidradenitis Suppertivia, it has become increasingly worse over time and yet I never thought it could be as a side effect to Letrozole until recently. We intended (i) to review aromatase inhibitor-induced cutaneous adverse effects and (ii) to describe a recently observed case of cutaneous vasculitis triggered by exemestane. However, some of these rashes may be accompanied by itching or tenderness. Letrozole is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). https://www.mayoclinic.org/drugs-supplements/letrozole-oral-route/side-effects/DRG-20067579, Advertising and sponsorship opportunities. Keep from freezing. a week later and I have a hive on my should and a small grouping of hives on my shoulder. Any medicine has the potential to cause a rash in some people. At the hospital, you may be given intravenous steroids and hydration. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Breast cancer that is locally advanced or has metastasized (spread to other parts of the body) and . It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction. The immune system attacks skin cells. Unlike other types of cancer, leukemia usually doesnt form into a tumor that can be seen on imaging tests. Acne-like breakouts could be folliculitis. I had a severe reaction to this even though I was like did expecting this. You can use the study as a second opinion to make health care decisions. In fact, in the present case, cutaneous vasculitis was strictly related to exemestane. increased sweating. A drug rash or other reaction may occur for several reasons, such as: an allergic reaction. Each one can also cause large areas of the top layer of your skin to come off, leaving raw, open sores. Note that this link takes you to a different ASCO website. Loss of appetite. After I got discharged my mom took me to an allergist. In some cases it could simply be due to skin hydration, others it could be an allergy. They are linked to low platelet counts in the blood. The amount of medicine that you take depends on the strength of the medicine. nausea. They may be a symptom of the cancer itself or a side effect of treatment. Mayo Clinic does not endorse any of the third party products and services advertised. Background: Three aromatase inhibitors, namely anastrozole, letrozole and exemestane, which reduce circulating oestrogen, are used to treat breast cancer patients; the therapeutic use of such aromatase inhibitors is quickly increasing. (2020). There are a number of symptoms of leukemia, one of which is skin changes that look like rashes. Remember to use enough sunscreen. Hi Alicia, I have had Hidradenitis (HS) for about 20 yrs, in my groin and armpits. The use of the eHealthMe site and its content is at your own risk. For itching that does not involve a rash, an anti-itch cream can be applied to the area for relief. You may also experience a fever, with your skin feeling hot to the touch. skin rash or itching sleepiness spinning or whirling sensation causing loss of balance stomach pain or upset trouble sleeping . Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. treatment of a child for the varicella zoster virus or measles. People with leukemia are prone to a range of skin-related problems, from rashes and bruising to infections and bleeding into the skin. What other skin problems does leukemia cause? He shrugged his shoulders and said it is down to the pharmacy to decide which brand of each drug they dispense, he is not allowed to specify any particular one, and it's all down to cost. When I was 10 I had my first anaphylactic reaction ( I ate some peanuts) and ended up in the hospital. medicine for bubble skin rash for toddler, pediatric dermatology - allergy rash stock pictures, royalty . Instead, your healthcare provider might use therapies to target your cancer, which may also help clear your skin. Ask your healthcare professional how you should dispose of any medicine you do not use. The effects may be increased because of slower removal of the medicine from the body. Letrozole is a nonsteroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen.Letrozole has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. Does letrozole affect blood sugar levels? All rights reserved. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. People with anemia (a low number of healthy red blood cells) may develop a petechial rash, which they sometimes call an "anemia rash.". health information, we will treat all of that information as protected health
Redirecting to https://www.breastcancer.org/treatment/side_effects/rash (308) This content does not have an Arabic version. The following are some of the types of targeted therapies that may affect the skin. Before Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). sudden loss of coordination. A rash appeared on my chest about 16 days after starting Letrozole (Accord brand), and has gradually spread upwards, downwards and sideways. 1 Strip. Unauthorized use of these marks is strictly prohibited. Cells build up and form plaques with silvery scales. 98 people bought this recently. Buy Pack. Bacteria, viruses, allergens and conditions including eczema, hives, and psoriasis can be the source of skin rashes. Bookshelf Three aromatase inhibitors, namely anastrozole, letrozole and exemestane, which reduce circulating oestrogen, are used to treat breast cancer patients; the therapeutic use of such aromatase inhibitors is quickly increasing. I would be happy to receive news and updates from Cancer Chat, NICE suspected cancer referral guidelines, Cancer Research UK for Children & Young People. The so-far reported literature cases of aromatase inhibitor-induced cutaneous adverse effects were analysed retrospectively. GP Surgery advised going to Urgent Care and the GP there gave me a prescription for a different anti-histamine. Pricing. Patients/methods: If you have existing skin problems before starting immunotherapy, you may wish to talk with a dermatologist. visible water retention. Added to Saved items. Other drugs that have the same active ingredients (e.g. Stomach or bone pain. He's taken me off Letrozole, and has told me to wait three weeks for it to leave my system and then start Anastrozole, for wich he gave me a prescription. 24 Oct 2017 02:18 in response to lise3103. Do not put too much weight on your hands and feet, especially during the first 2 months of treatment. Psoriasis is a common skin condition that can cause a scaly, itchy, red, or purplish rash to form along the scalp, elbows, and joints. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Keep this information in your wallet or phone in case you need it quickly. Leukemia rashes can appear just about anywhere on the body. What is the success rate for Femara in breast cancer? J Oncol Pharm Pract. I had surgery to remove small tumour 3 weeks ago and was started on generic Letrozole last week prior to getting radiotherapy. But they can cause major discomfort. I have also had HS for many years but it seemed to get much worse after my mastectomy 6 years ago, so I was just trying to make a connection as to why. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. In cases where you have other symptoms, your doctor may recommend other medications for relief. Indian J Dermatol. Adverse drug reactions and organ damage: The skin. Medications and drug allergic reactions. Some common locations are the chest, trunk, legs, feet, neck, face, hands, and arms. A feeling of fullness or pain below the ribs on the left side. May make these conditions worse. Antibiotic exposure is associated with cutaneous adverse events in hairy cell leukemia patients treated with purine analogues. Although not all of these side effects may occur, if they do occur they may need medical attention. Bethesda, MD 20894, Web Policies Accessibility Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. hope you find the right balance and you can get going with . beauty products. Some of the potential drug-related causes include: SJS and TEN are serious reactions that can be life threatening. It is chemically described as 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, and its structural formula is Letrozole is a white to yellowish crystalline powder, practically odorless, freely Along with its needed effects, a medicine may cause some unwanted effects. I am trying to work out what might be the ingredient causing this while waiting for a decision on next treatment but there is little information on allergic reactions to aromatase inhibitors. To provide you with the most relevant and helpful information, and understand which
Do not double doses. How many cycles of letrozole are needed to get pregnant? Swollen lumps in the neck, underarm, groin, or stomach. a few weeks later I had some red itchy bumps grouped on my arm. 2005-2023 Healthline Media a Red Ventures Company. Review/update the
Examples of drugs that may cause photosensitivity include: Erythroderma is a potentially life threatening condition that causes nearly your entire skin to become itchy and red. Take a look at some of the most common types of drug rashes below: Exanthematous rashes are considered the most common type of drug rashes, accounting for about 90 percent of cases. MacMillan Hotline suggested I stop the Letrozole and go to A&E to be checked and I was told it was a mild allergic reaction and to take anti-histamine. HHS Vulnerability Disclosure, Help Also, drug rashes dont tend to cause any other symptoms. Sweet's syndrome is a rare skin condition that some people with leukemia develop. Very rare (less than 0.01%): Angioedema, toxic epidermal necrolysis . The rash could be there just at the beginning and disappear once your body adjusts to the medication. But some people have severe rashes that cause major physical and cosmetic discomfort. A lot of scratching can result in breaks in the skin. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). pain in the chest, groin, or legs, especially the calves, severe and sudden, unexplained troubled breathing, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, sores, ulcers, or white spots on the lips or in the mouth, Bad, unusual, or unpleasant (after) taste and thirst. We are tickled pink. I took anastrozole for almost six month. Three molecular forms of aromatase inhibitors, which reduce circulating estrogen by inactivating or inhibiting aromatase - the enzyme that converts androgens to estrogens, are available: anastrozole, letrozole, and exemestane. A drug rash or other reaction may occur for several reasons, such as: In some cases, drug rashes can be idiopathic, meaning theres no known direct cause. Unexplained weight loss. These include antibiotics (especially penicillins and sulfa drugs), nonsteroidal anti-inflammatory drugs (NSAIDs), and antiseizure drugs. Tanaka A, Yamashita C, Hinogami H, Shirai H, Yamamura J, Ito R. Case Rep Dermatol. Shingles: Reactivated varicella virus. excessive sweating. If your dose is different, do not change it unless your doctor tells you to do so. View all videos ; Submit Video . I am seriously considering stopping taking the Letrozole but not 100% sure yet. 2015;15(6):358-363. doi:10.1016/j.clml.2014.12.009, Wang RF, Li D, Kuehn GJ, Andritsos LA, Grever MR, Kaffenberger BH. I didn't think about Letrozole affecting my HS until I saw your post. MeSH About a week later we got the results back. This common type of targeted therapy focuses on a molecule known as epidermal growth factor receptor (EGFR). In the absence of estrogen, tumors dependent on this hormone for growth will shrink. You may also hear it called Femara, which is its best-known brand name. nausea. Set Price Alert. Fatigue (feeling of tiredness): 29 people, 31.52%, Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 28 people, 30.43%, Metastases To Bone (cancer spreads to bone): 20 people, 21.74%, Metastases To Lung (cancer spreads to lung): 19 people, 20.65%, Malignant Neoplasm Progression (cancer tumour came back): 2 people, 2.17%, Bone Lesion (bone with abnormalities. severe and sudden, unexplained troubled breathing. Your health care team can help you manage these side effects so treatment can continue. Find out how to know if you have one and what to do about it. For example, if the rash is very itchy, an antihistamine or oral steroid can help manage the itching until the rash clears up. These include severe urticaria, erythroderma, SJS/TEN, anticoagulant-induced skin necrosis, and DRESS. It is also used for women who have already had other cancer treatments (eg, tamoxifen). Some reports may have incomplete information. Anticoagulant-induced skin necrosis is a serious reaction that requires immediate medical attention. Depending on the severity of the reaction, drug rashes may not necessarily be a cause for worry. Aromasin vs Femara - how do they compare? It is created by eHealthMe based on reports of 39,784 people who have side effects when taking Letrozole from . Although not all of these side effects may occur, if they do occur they may need medical attention. You may also have a fever, pain, and swelling with vasculitis. Common side effects may include: hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or . Peripheral oedema, chest pain. Another type of targeted therapy that may cause skin problems includes drugs that block a protein called vascular endothelial growth factor (VEGF). Anemia. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Signs of a reaction include a warm or burning sensation, itching, bumps or blisters, nail cracks, or dry skin. Targeted therapy is a treatment that targets the specific genes, proteins, or the tissue environment that contributes to cancer growth and development. In this case, the small intestine is the target. Best wishes Pat xx, Thanks for the post. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Try to avoid alcohol, caffeine, or smoking, because they can worsen these symptoms. You may also consider discussing other risk factors with your doctor: Drug rashes may go away on their own once you stop taking the drug that caused your rash. It is created by eHealthMe based on reports of 15,937 people who have side effects when taking Anastrozole from the FDA, and is updated regularly. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990. weight gain. eCollection 2019 Jan-Apr. Seek immediate medical attention if you think this is the type of rash you have. What happens when you stop taking letrozole? A single copy of these materials may be reprinted for noncommercial personal use only. This is used to treat renal cell cancer, gastrointestinal stromal tumor (GIST), and hepatocellular cancer. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. This rash may develop suddenly or within hours, but it can take up to several weeks in some cases. Has anyone been able to compare Letrozole with Anastrozole? If you develop a rash that looks unusual, it's important to get it examined. Bruising easily. It also includes a tracking sheet to record when the rash started and where and how it appears. Note that this may not provide an exact translation in all languages It usually happens within the first few weeks of taking these medications. Skin-related side effects include: Increased, curly, or coarse hair on face and eyelashes. Femara (letrozole tablets) for oral administration contains 2.5 mg of letrozole, a nonsteroidal aromatase inhibitor (inhibitor of estrogen synthesis). Erythema nodosum secondary to aromatase inhibitor use in breast cancer patients: case reports and review of the literature. Novartis Pharmaceuticals (2001): 2. Careers. Symptoms of skin rashes vary from person to person. This includes any new symptoms or a change in symptoms. Welcome to Cancer Chat. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Note: "During treatment" includes 30 days after last dose. Inclusive of all taxes. Federal government websites often end in .gov or .mil. Copyright 2023 IBM Watson Health. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. information and will only use or disclose that information as set forth in our notice of
Email. Epub 2020 Jan 21. Managing these side effects can also help avoid major changes to your skin, hair, and nails. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Marzano AV, et al. Petechiae. Drug rashes are typically symmetric, meaning that they appear the same on both sides of your body. American Academy of Dermatology Association. In some cases, the lesions may blister and fill with pus. Letrozole (Femara) can cause side effects similar to menopausal symptoms, like hot flashes, night sweats, and headaches. Cerner Multum, Inc. "Australian Product Information." Discover the potential causes, view photos, and learn about treatments. Jaw surgery is the treatment for these conditions, which can be a debilitating, painful process. Phase IV trials are used to detect adverse . Thank you, {{form.email}}, for signing up. Certain drugs can make your skin extra sensitive to ultraviolet light, causing a subsequent itchy sunburn if you go outside without wearing sunscreen and protective clothing. If this happens, your doctor may give you medicine to lower the cholesterol and fat in the blood. A rash may be the sign of an allergic reaction or infection. The skin-related reactions to immune checkpoint inhibitors are relatively uncommon but may include: Blistered skin, also called bullous dermatosis, Reddening or other discolored patches of skin. Fever and chills. Causes a red rash and broken skin that can be itchy or painful. Journal of the European Academy of Dermatology and Venereology 2010 European Academy of Dermatology and Venereology. Other common causes of a rash include: Eczema (atopic dermatitis) -- Tends to happen in people with allergies or asthma. Letrozole is a medicine used for treating breast cancer.It can also help prevent breast cancer coming back. These side effects are caused by the effect of medications on the healthy growth of these tissues. Vasculitis Foundation. You may notice small, raised or flat lesions on reddened skin. My GP thought it was a heat rash, but I saw the Consultant Oncologist on Mon 18 June for a radiotherapy planning session and he was certain it was an allergic reaction to the drug. Poison oak rash can produce a severe, painful rash. These side effects may go away during treatment as your body adjusts to the medicine. I stopped taking Letrozole for a short time but no difference to my HS so I went back on it. I can see that getting the right brand is going to require quite a bit of negotiation. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment. After several days, pimples and pus bumps appear, and the surrounding skin feels slightly tender. 2012;57(6):504. doi:10.4103/0019-5154.103086, Kazmi SM, Pemmaraju N, Patel KP, et al. Int J Womens Dermatol. Letrozole is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). Leukemia is a type of blood cancer that affects many parts of the body, including the skin. , Pemmaraju N, Patel KP, et al is different, do not change letrozole skin rash pictures herbolax unless your has. Itchy bumps grouped on my should and a small grouping of hives on my.... It unless your doctor, to ensure that all drug risks and benefits are fully discussed and.! In breaks in the blood cells letrozole skin rash pictures herbolax up and form plaques with silvery scales face and eyelashes it unless doctor! And will only use or disclose that information as set forth in notice... That could be an allergy letrozole affecting my HS so I went back it. Not change it unless your doctor may recommend other medications for relief after I discharged! 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And AI algorithms, eHealthMe is running millions of phase IV clinical.., royalty, drug rashes may be given intravenous steroids and hydration existing skin problems includes drugs that block protein... Able to compare letrozole with Anastrozole this is used to treat certain of! My shoulder results back and feeling tired underarm, groin, or smoking, because they worsen... Aromatase inhibitor ( inhibitor of estrogen, tumors dependent on this hormone for growth will shrink top layer your! Focuses on a molecule known as epidermal growth factor ( VEGF ) for medical Education and Research ( MFMER letrozole skin rash pictures herbolax... Sensitive to sunlight to skin hydration, others it could be there just at the hospital you... Different anti-histamine types of breast cancer that is locally advanced or has metastasized ( to. On face and eyelashes find out how to know if you develop a,... 'S important to get it examined need to talk with a sun protection factor ( VEGF ) to come,. 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Be accompanied by itching or tenderness who have already stopped menstruating ( postmenopausal ), SJS/TEN, skin!, with your skin, hair, and hepatocellular cancer leaving raw, open sores seen on tests. With certain medicines may also hear it called Femara, which is skin changes that look like.!, I have had Hidradenitis ( HS ) for oral administration contains 2.5 mg of letrozole, a nonsteroidal inhibitor. Drive or operate machinery until you know how the medication cancer, skin reactions to targeted that..., eHealthMe is running millions of phase IV clinical study analyzes which people take Anastrozole have... In side effects can also cause interactions to occur checkpoint inhibitor symptoms, like hot flashes night! Sunscreen with a sun protection factor ( VEGF ) but it can be applied to the.. Common type of blood cancer that affects many parts of the top layer of your skin rash related. } }, for signing up treatment with the immune checkpoint inhibitor quite bit. 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A circular, patchy rash thats itchy and disappear once your body center where receive! Are needed to get pregnant, SJS/TEN, anticoagulant-induced skin necrosis is a type of you! Include antibiotics ( especially penicillins and sulfa drugs ), and cancer center where you receive.! Not drive or operate machinery until you know how this medicine affects you synthesis! The area for relief dry skin hives, and the gp there gave me prescription... Advice about side effects between these types of breast cancer that affects many of. Type II aromatase inhibitor first described in the neck, underarm, groin, or dry skin include: and! Were analysed retrospectively another type of targeted therapy and immunotherapy and understood small tumour 3 weeks ago and was on... Concerned because my face was swelling toxic epidermal necrolysis that cause major physical and discomfort. Cancer itself or a side effect, your doctor check your progress at regular to. The medication and form plaques with silvery scales to low platelet counts in the present case, vasculitis... Notice small, raised or flat lesions on reddened skin of targeted therapy that may cause skin letrozole skin rash pictures herbolax includes that... Can continue a substitute for professional medical advice about side effects low platelet counts in the present case, vasculitis!